Submodule 6A

Reproductive Toxicology, S&B Chapter 6

1. Vocabulary: mitosis, meiosis, chromatin, autosomal chromosomes, alleles, X and Y chromosomes, haploid, diploid, crossing over, testes, seminiferous tubules, testosterone, LH, FSH, GnRF, spermatozoa, semen, blood- testis, ovaries, fallopian tubes, uterus, endometrium, primary oocytes, primary follicles, secondary follicles, secondary oocyte, polar body, zygote, placenta, teratology, teratogen, Multi-generational reproduction test.
2. Understand basic feedback control and steroid hormone control of reproduction and that any chemical that disturbs these hormones may affect reproduction.
3. Basic idea of chromosomal abnormalities

4. How might a child be exposed to phthalate esters?

5. The great range of chemicals and other insults to various stages of reproduction.

6. Sensitivity during organogensis

7. Breast milk as an exposure route for infants.

Submodule 6B

Reproductive Examples

1. Describe the thalidomide tragedy. What went wrong with the system?

2. DES. What happened. Multi-generational studies.

Submodule 6C

Respiratory Toxicology, S&B Chapter 7

 1. Vocabulary: conducting airways, cilia, mucus, bronchioles, alveoli, surfactant, Clara cell, macrophage, parenchyma, stroma, elastic recoil, pneumoconiosis,
3. Describe irritation to conducting airways, what happens.

7. Describe the change in velocity, airway diameter, and airway surface area, going from trachea to alveoli.

Submodule 6D

Particulates

 Differentiate the causes of asbestosis vs. silicosis.

Submodule 6E

Resources:

IRIS, ATSDR, IARC